Radiomics to predict high risk features in intraocular retinoblastoma.

Among 31 eyes of 29 patients, 14 eyes had optic nerve invasion and 6 had choroidal invasion.

The predictive model for optic nerve (optic nerve) invasion achieved Area under the receiver operating characteristic curve (AUROC) of 0.85 (accuracy 0.84, sensitivity 0.93, specificity 0.76) using the radiomic features of maximum 2D diameter slice on the unaffected optic nerve (optic nerve), correlation of grey level co-occurrence matrix (GLCM) on the affected optic nerve, and kurtosis of affected optic nerve.