Non-invasive prediction of the secondary enucleation risk in uveal melanoma based on pretreatment CT and MRI…

Cohort studyStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]· May 2026

Non-invasive prediction of the secondary enucleation risk in uveal melanoma based on pretreatment CT and MRI prior to stereotactic radiotherapy.

Yagiz Yedekci, Hidetaka Arimura, Yu Jin … Gozde Yazici

Ocular OncologyCohort studyPrognosisQ2IF 2.1

Computed tomography+magnetic resonance radiomic model predicts secondary enucleation risk in uveal melanoma with AUC 0.90

Non-invasive prediction of the secondary enucleation risk in uveal melanoma based on pretreatment CT and MRI prior to stereotactic radiotherapy.

Yagiz Yedekci … Gozde Yazici

Strahlentherapie und Onkologie · May 2026

Purpose

The aim of this study was to develop a radiomic model to non-invasively predict the risk of secondary enucleation (SE) in patients with uveal melanoma (uveal melanoma) prior to stereotactic radiotherapy using pretreatment computed tomography (computed tomography) and magnetic resonance (magnetic resonance) images.

Methods

This retrospective study encompasses a cohort of 308 patients diagnosed with uveal melanoma who underwent stereotactic radiosurgery (stereotactic radiosurgery) or fractionated stereotactic radiotherapy (fractionated stereotactic radiotherapy) using the CyberKnife system (Accuray, Sunnyvale, CA, USA) between 2007 and 2018.

n = 308 patients

0.90

Results

0.90

higher score means better prediction of who will need eye removal

n = 308 patients

More results

The feature of robust mean absolute deviation derived from the Laplacian-of-Gaussian-filtered magnetic resonance images was identified as the most significant predictor, demonstrating a statistically significant difference between SE+ and SE- cases (p = 0.005).

“

Conclusion · 1 of 2

Radiomic analysis of pretreatment computed tomography and magnetic resonance images can non-invasively predict the risk of SE in uveal melanoma patients undergoing stereotactic radiosurgery/fractionated stereotactic radiotherapy.

Conclusion · 2 of 2

The combined computed tomography + magnetic resonance radiomic model may inform more personalized therapeutic decisions, thereby reducing unnecessary radiation exposure and potentially improving patient outcomes.

Non-invasive prediction of the secondary enucleation risk in uveal melanoma based on pretreatment CT and MRI prior to stereotactic radiotherapy.

Non-invasive prediction of the secondary enucleation risk in uveal melanoma based on pretreatment CT and MRI prior to stereotactic radiotherapy.

Related papers