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New research · Ophthalmology
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 17h
Cohort studyCanadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2026

Ocular surface squamous neoplasia: insights from 67 cases at a Quebec tertiary center.

Rayan Tolba, Grace Lin, Sonia Callejo … Marie-Claude Robert
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OphthalmologyCohort study

Most biopsied ocular surface squamous neoplasia lesions are high-grade at diagnosis

Ocular surface squamous neoplasia: insights from 67 cases at a Quebec tertiary center.

Rayan Tolba … Marie-Claude Robert
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2026
Purpose

To evaluate the demographics, clinical characteristics, treatments, and outcomes of patients with ocular surface squamous neoplasia (ocular surface squamous neoplasia).

Methods

Followed for ocular surface squamous neoplasia at the Centre Hospitalier de l'Université de Montréal in Quebec between 2013 and 2024.

n = 67 eyes
Results

most biopsied lesions were already higher-grade, not early-stage, at diagnosis

CIN
87%
SCC
13%
More results

In total, 67 eyes from 66 patients with a median age at diagnosis of 71 years (range 43-92) were identified.

Of the patients, 67.2% (n = 45) were male, and 25.5% (n = 13/51) had a history of skin cancer.

Lesions most frequently presented on the bulbar conjunctiva (41%, n = 57), the limbus (25.9%, n = 36), and/or the cornea (13.7%, n = 18).

More results

On Cox regression, recurrences were not associated with specific treatment approaches (all hazard ratio CIs crossing 1; P > 0.639) but were associated with positive margins (hazard ratio 3.892; P = 0.04).

“
Conclusion · 1 of 2

Ocular surface squamous neoplasia in Quebec predominantly presents as papillomatous bulbar conjunctival lesions in the older White men.

Conclusion · 2 of 2

In total, 83% of biopsied lesions are of a higher grade (CIN3 and SCC), warranting efforts for earlier detection and referral.

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