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StudyRadiation and environmental biophysics · 2026

Monte Carlo simulation of uveal melanoma treatment by ocular plaque brachytherapy using gold nanoparticles.

Seyed MohammadAli Moeini, Sedigheh Sina, Payman Rafiepour, Zahra Siavashpour

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OphthalmologyStudy

Gold nanoparticles raised simulated tumour dose from cesium-131 seeds nearly 4-fold.

Monte Carlo simulation of uveal melanoma treatment by ocular plaque brachytherapy using gold nanoparticles.

Seyed MohammadAli Moeini … Zahra Siavashpour

Radiation and environmental biophysics · 2026

Background

Uveal melanoma is a serious ocular disease that can be fatal.

377.23%

Results

377.23%

tumour radiation dose measured with nanoparticles added versus without - nearly 4-fold higher

More results

One of its treatment methods involves the use of radioactive seeds, which are temporarily attached to a plaque and placed on the eye.

The dose distribution around the seeds used in ocular plaques strongly depends on the seeds' structure and the ocular plaque's design.

More results

The results show that the average doses received by the different eye structures and the tumour vary depending on the seed model.

The tumour apex dose increases with increasing concentration of gold nanoparticles within the tumour volume, hence reducing the irradiation time.

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Conclusion

Furthermore, gold nanoparticles decreased the dose delivered to surrounding eye components, particularly for 103 Pd brachytherapy, where the lens has the greatest reduction in dose among all eye components, ranging from 7.57% at 5 mgAu/g to 33.27% at 30 mgAu/g.

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Monte Carlo simulation of uveal melanoma treatment by ocular plaque brachytherapy using gold nanoparticles.

Gold nanoparticles raised simulated tumour dose from cesium-131 seeds nearly 4-fold.

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