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Cohort studyInternational ophthalmology clinics · 2025

Intra-arterial Chemotherapy for Retinoblastoma: Real-world Experience.

Abhishek Das, Kothapally Saiteja, Parag K Shah … Narendran Venkatapathy

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OphthalmologyCohort study

Intra-arterial chemotherapy achieved globe salvage in most retinoblastoma eyes treated

Intra-arterial Chemotherapy for Retinoblastoma: Real-world Experience.

Abhishek Das … Narendran Venkatapathy

International ophthalmology clinics · 2025

Background

Intra-arterial chemotherapy (intra-arterial chemotherapy) has emerged as a standard of care for retinoblastoma (retinoblastoma).

Methods

This retrospective study analyzed 20 patients (n=21 eyes) with retinoblastoma treated with intra-arterial chemotherapy at a single tertiary center.

n = 21 eyes

Results

81%

most treated eyes were saved, avoiding surgical eye removal

n = 21 eyes

More results

Our study evaluates the outcomes, adverse effects and challenges of intra-arterial chemotherapy in the management of retinoblastoma in an Indian cohort.

Drugs used were melphalan (5/7.5 mg) and topotecan (1/2 mg) (n=14) or melphalan (5 mg) alone (n=3) or triple therapy, which included carboplatin (30 mg) along with these drugs (n=4).

More results

Complete regression of the main tumor was seen in 12 eyes (57%) and partial regression in 9 eyes (43%).

“

Conclusion

This study provides critical insights into the real-world application of intra-arterial chemotherapy in resource-limited settings, highlighting both its promise and limitations.

Post

Intra-arterial Chemotherapy for Retinoblastoma: Real-world Experience.

Intra-arterial chemotherapy achieved globe salvage in most retinoblastoma eyes treated

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