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New research · Ophthalmology
Neurological research · 19h
Meta-analysisNeurological research · 2026

Potential therapeutic role of GLP-1 receptor agonists in Idiopathic intracranial hypertension: a systematic review and meta-analysis.

Jiahao Song, Kun Fang, Yunzhou Zhang … Daiquan Gao
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OphthalmologyMeta-analysis

GLP-1 receptor agonist use linked to lower papilledema risk in idiopathic intracranial hypertension.

Potential therapeutic role of GLP-1 receptor agonists in Idiopathic intracranial hypertension: a systematic review and meta-analysis.

Jiahao Song … Daiquan Gao
Neurological research · 2026
Background

Idiopathic intracranial hypertension (intracranial hypertension) is a neurological disorder characterized by elevated intracranial pressure (intracranial pressure) , often resulting in headaches and visual impairment.

Methods

We systematically searched PubMed, Embase, Web of Science, Scopus, and the Cochrane Library up to July 2025, following PRISMA guidelines.

n = 11,973 participants
Results

GLP-1 drug users had markedly lower risk of swollen optic nerves

RR by subgroup · 95% CI
null = 1
papilledema
0.40
as well as visual disturbances and
0.51
headache incidence
0.74
More results

However, no significant improvements were observed in objective visual parameters, including visual acuity, visual field, or peripapillary retinal nerve fiber layer (pRNFL) thickness.

GLP-1RA therapy was associated with reduced headache incidence (RR = 0.74, 95% CI: 0.54-1.00) and fewer monthly headache days (SMD = -0.77, 95% CI: -1.35 to -0.19).

More results

Changes in BMI were not significant (SMD = -0.06, 95% CI: -0.15 to 0.02).

“
Conclusion · 1 of 2

GLP-1RAs show promise as adjunctive therapies for intracranial hypertension, offering improvements in refractory intracranial hypertension, papilledema, and headache burden.

Conclusion · 2 of 2

Further large-scale randomized controlled trials are needed to confirm these findings.

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