Multistream Deep Learning Models Using Multimodal Optical Coherence Tomography for Predicting Visual…

AI / informaticsAmerican journal of ophthalmology· Feb 2026

Multistream Deep Learning Models Using Multimodal Optical Coherence Tomography for Predicting Visual Impairment in Epiretinal Membrane.

Hsu-Hang Yeh, Po-Yung Chou, Cheng-Chang Hsieh … Cheng-Hung Lin

Community Eye HealthAI / informaticsDiagnosisQ1IF 4.2

An eight-image AI model best predicted visual impairment from epiretinal membrane.

Multistream Deep Learning Models Using Multimodal Optical Coherence Tomography for Predicting Visual Impairment in Epiretinal Membrane.

Hsu-Hang Yeh … Cheng-Hung Lin

American journal of ophthalmology · Feb 2026 · Q1 in Ophthalmology

Purpose

To develop multistream deep learning models that receive multimodal optical coherence tomography (optical coherence tomography) images to predict visual impairment in epiretinal membrane (epiretinal membrane), and to identify possible optical coherence tomography biomarkers for visual impairment.

Methods

Who were diagnosed as idiopathic epiretinal membrane at one medical center were retrospectively enrolled.

n = 351 sets of images

Results

90.90%

The combined eight-image deep learning model correctly predicted vision loss in 90.90% of cases.

n = 351 sets of images

More results

The single-stream models achieved accuracies ranging from 79.48% to 88.89% in model development but decreased to 60.69%-75.11% in external validation.

Increasing the number of input streams to two or three further enhanced predictive performance.

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Conclusion · 1 of 2

B-scan optical coherence tomography, en face optical coherence tomography angiography and retinal thickness maps of the macula could all be used for predicting visual impairment in epiretinal membrane via deep learning.

Conclusion · 2 of 2

The multistream design can enhance predictive accuracy and may provide localization of vital retinal regions relevant to visual compromise in epiretinal membrane.

Multistream Deep Learning Models Using Multimodal Optical Coherence Tomography for Predicting Visual Impairment in Epiretinal Membrane.

Multistream Deep Learning Models Using Multimodal Optical Coherence Tomography for Predicting Visual Impairment in Epiretinal Membrane.

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