Post

New research · Ophthalmology
Molecular vision · 22h
Animal / preclinicalMolecular vision · 2025

System biology analysis reveals that Grm6 is associated with glutamate accumulation-induced scotopic vision impairment in diabetic mice.

Ying Lian, Yanpu Zhao, Xiaoyu Yang … Yanping Zhu
Read paper
OphthalmologyAnimal / preclinical

Grm6 gene activity was most strongly linked to blood glucose in diabetic mice

System biology analysis reveals that Grm6 is associated with glutamate accumulation-induced scotopic vision impairment in diabetic mice.

Ying Lian … Yanping Zhu
Molecular vision · 2025
Background

Scotopic vision impairment as an early event is found in diabetic retinopathy.

Purpose

This study aims to identify that Grm6 is associated with glutamate accumulation-induced scotopic vision impairment under hyperglycemia.

Methods

In this study, diabetic mice with impaired scotopic vision were induced by streptozotocin, and the retinal electrical activity was evaluated using electroretinography.

Results
R=-0.5291
lower Grm6 gene activity strongly linked to higher blood glucose
More results

In total, 151 proteins were significantly altered in the retina of diabetic mice.

Among these 151 candidates, 22 genes presented a significant correlation with blood glucose level (p<0.05), which were enriched in alanine, aspartate, and glutamate metabolism (p=0.003).

More results

Moreover, the glutamate catabolism-related genes Slc1a2, Gad1, and Glud1 were significantly negatively correlated with blood glucose at the transcript and proteome levels, which led to glutamate accumulation under hyperglycemia.

Moreover, Grm6 expression was significantly decreased at both the mRNA and protein levels in the diabetic retina.

“
Conclusion

Our study confirms that Grm6 is associated with scotopic vision impairment induced by glutamate accumulation in diabetic mice and provides an efficient strategy for exploring critical biomarkers and pathways through a combination of proteomics and transcriptome-wide association analysis.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
AI / Informatics
0·962 for OCT
MerMED-FM was very accurate at diagnosing diseases using eye scans
AI / Informatics
0.98
Artificial intelligence's eyelid-height measurements matched doctors' manual measurements almost perfectly
AI / Informatics
92.1%
combining eye scans and photos correctly told benign from cancerous lesions apart nearly every time
Cohort Study
28.6%
recurred locally in more than 1 in 4 patients over years of follow-up
Cohort Study
-0.395
excision group's post-op eyelid fullness score was lower - greater improvement
Cohort Study
86.7%
of infants probed after 12 months still had unresolved tear duct blockage
Observational
16%
eyelid tissue in rosacea patients showed less of this key repair-signaling protein inside cell nuclei
Cohort Study
25%
about 1 in 4 treated cases had symptoms return after improving