Post

New research · Ophthalmology
Molecular vision · 23h
Animal / preclinicalMolecular vision · 2025

System biology analysis reveals that Grm6 is associated with glutamate accumulation-induced scotopic vision impairment in diabetic mice.

Ying Lian, Yanpu Zhao, Xiaoyu Yang … Yanping Zhu
Read paper
OphthalmologyAnimal / preclinical

Grm6 gene activity was most strongly linked to blood glucose in diabetic mice

System biology analysis reveals that Grm6 is associated with glutamate accumulation-induced scotopic vision impairment in diabetic mice.

Ying Lian … Yanping Zhu
Molecular vision · 2025
Background

Scotopic vision impairment as an early event is found in diabetic retinopathy.

Purpose

This study aims to identify that Grm6 is associated with glutamate accumulation-induced scotopic vision impairment under hyperglycemia.

Methods

In this study, diabetic mice with impaired scotopic vision were induced by streptozotocin, and the retinal electrical activity was evaluated using electroretinography.

Results
R=-0.5291
lower Grm6 gene activity strongly linked to higher blood glucose
More results

In total, 151 proteins were significantly altered in the retina of diabetic mice.

Among these 151 candidates, 22 genes presented a significant correlation with blood glucose level (p<0.05), which were enriched in alanine, aspartate, and glutamate metabolism (p=0.003).

More results

Moreover, the glutamate catabolism-related genes Slc1a2, Gad1, and Glud1 were significantly negatively correlated with blood glucose at the transcript and proteome levels, which led to glutamate accumulation under hyperglycemia.

Moreover, Grm6 expression was significantly decreased at both the mRNA and protein levels in the diabetic retina.

“
Conclusion

Our study confirms that Grm6 is associated with scotopic vision impairment induced by glutamate accumulation in diabetic mice and provides an efficient strategy for exploring critical biomarkers and pathways through a combination of proteomics and transcriptome-wide association analysis.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cross-sectional
44.1%
had too much homocysteine in the blood, a far larger share than in dry AMD or healthy eyes
Cohort Study
92.3%
most laser-treated eyes had a favorable eye-structure outcome
Cohort Study
56%
lost three or more lines on the eye-chart vision test
Cohort Study
50%
older patients were more likely to lose three or more lines of vision
Study
81%
trials where mask air leaks were detected blowing toward the eyes
Cohort Study
13.5%
Central retinal artery peak blood-flow speed was 13.5% lower in diabetic patients.
Study
379 +/- 156 microm
lower thickness in the central retina, checked with an eye scan
Case Report
9 of 10 eyes
eyes had better measured vision after treatment