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Cohort studymBio · 2026

Phylogenetic diversity, functional pathways, and network interactions of ocular chlamydia-like organisms (CLOs) in trachoma-endemic Ethiopia.

Olusola Olagoke, Xinhe Zheng, Seongwon Chung … Deborah Dean

OphthalmologyCohort study

Chlamydia-like ocular organisms found in 23.3% of Ethiopian villagers studied.

Phylogenetic diversity, functional pathways, and network interactions of ocular chlamydia-like organisms (CLOs) in trachoma-endemic Ethiopia.

Olusola Olagoke … Deborah Dean

mBio · 2026

Background

Trachoma is the leading infectious cause of blindness worldwide and classically attributed to C hlamydia trachomatis (Ct).

23.3%

Results

23.3%

nearly 1 in 4 villagers carried these bacteria in their eyes

n = 1,059 individuals

More results

Here, we investigated chlamydia-like organisms distribution, phylogeny, and microbiome associations among 1,059 individuals from trachoma-endemic communities in Ethiopia using targeted 16S rRNA sequencing and metagenomic shotgun sequencing.

More results

Chlamydia-like organisms-positive microbiomes exhibited significantly greater species richness and evenness with distinct differences in community composition relative to chlamydia-like organisms-negative microbiomes.

“

Conclusion

Further research on their interactions with ocular microbial communities could reveal new insights into trachoma pathogenesis and inform more holistic approaches to disease control.

Post

Phylogenetic diversity, functional pathways, and network interactions of ocular chlamydia-like organisms (CLOs) in trachoma-endemic Ethiopia.

Chlamydia-like ocular organisms found in 23.3% of Ethiopian villagers studied.

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