Phylogenetic diversity, functional pathways, and network interactions of ocular chlamydia-like organisms (CLOs) in trachoma-endemic Ethiopia.

Here, we investigated chlamydia-like organisms distribution, phylogeny, and microbiome associations among 1,059 individuals from trachoma-endemic communities in Ethiopia using targeted 16S rRNA sequencing and metagenomic shotgun sequencing.

Chlamydia-like organisms-positive microbiomes exhibited significantly greater species richness and evenness with distinct differences in community composition relative to chlamydia-like organisms-negative microbiomes.