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Cohort studyAmerican journal of translational research · 2026

Factors influencing refractive status distribution and amblyopia in preschool children with low vision.

Jun Wu, Jili Wen, Yong Yang, Jialing He

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OphthalmologyCohort study

Amblyopia affected 40% of preschoolers with low vision in this cohort.

Factors influencing refractive status distribution and amblyopia in preschool children with low vision.

Jun Wu … Jialing He

American journal of translational research · 2026

Purpose

To reveal the distribution characteristics of refractive status of preschool children with low vision, analyze the independent risk factors of amblyopia (amblyopia), and build a risk prediction model, so as to provide a basis for early screening and precise intervention.

Methods

We enrolled 180 preschoolers (3-6 years old) with low vision from January 2023 to December 2024.

n = 180 preschoolers

Results

40.00%

these children were diagnosed with amblyopia on exam

n = 180 preschoolers

More results

Hyperopia was dominant in children with low vision.

With an increase in age, the proportion of hyperopic refractive error gradually decreased.

According to multivariate analysis, parental myopia, time spent on close-range eye use, and refractive status were independent risk factors for amblyopia.

More results

Through internal validation, it was found that the prediction model had clinical application value in amblyopia screening.

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Conclusion · 1 of 2

The main refractive abnormality in preschool children with low vision is hyperopic refractive error, which is also the core risk factor for amblyopia.

Conclusion · 2 of 2

The risk prediction model we constructed can effectively identify high-risk groups, providing an efficient tool for early clinical screening.

Post

Factors influencing refractive status distribution and amblyopia in preschool children with low vision.

Amblyopia affected 40% of preschoolers with low vision in this cohort.

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