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New research · Ophthalmology
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 1d
Cohort studyJournal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2026

Comparative outcomes for treatment of type 1 retinopathy of prematurity in a contemporary cohort.

Anne Strong Caldwell, Jennifer Patnaik, Lauren Mehner … Jennifer Jung
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OphthalmologyCohort study

Most infants treated for type 1 retinopathy of prematurity achieved 20/40 or better vision.

Comparative outcomes for treatment of type 1 retinopathy of prematurity in a contemporary cohort.

Anne Strong Caldwell … Jennifer Jung
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2026
Background

Data comparing treatment outcomes between these modalities are heterogenous and limited by short-term follow-up.

Purpose

The purpose of this study was to investigate visual acuity, structural outcomes, and refractive error (refractive error) between primary laser and primary intravitreal injections in a contemporary cohort treated for retinopathy of prematurity.

Methods

The medical records of patients treated for type 1 retinopathy of prematurity at a tertiary care center from 2006 to 2022 were reviewed retrospectively.

n = 358 eyes
Results
60%
most treated infants had vision sharp enough to pass a driving test
n = 358 eyes
More results

A total of 179 patients (358 eyes) received treatment for type 1 retinopathy of prematurity.

Most patients received primary laser therapy (83.5%).

We were able to collect formal visual acuity testing on 92 eyes.

More results

There was no difference in adverse ocular outcomes or refractive error between the primary laser and primary intravitreal injections groups.

“
Conclusion · 1 of 2

In contrast to prior studies, there were no differences in adverse ocular outcomes between infants treated with primary intravitreal injections and those treated with primary laser for retinopathy of prematurity.

Conclusion · 2 of 2

Our study demonstrates high effectiveness of both treatments, with low rates of retinal detachment and blindness.

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