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New research · Ophthalmology
The American journal of tropical medicine and hygiene · 1d
StudyThe American journal of tropical medicine and hygiene · 2026

The Diverse Spectrum of Presumed Ocular Tuberculosis Including Optic Neuropathy in a Tuberculosis-Endemic Region: A Case Series from India.

Anita Ambasta, Rakhi Kusumesh, Rajnee Sinha … Varuni Pragya
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OphthalmologyStudy

Antitubercular therapy-induced optic neuropathy occurred in 26 patients with ocular tuberculosis.

The Diverse Spectrum of Presumed Ocular Tuberculosis Including Optic Neuropathy in a Tuberculosis-Endemic Region: A Case Series from India.

Anita Ambasta … Varuni Pragya
The American journal of tropical medicine and hygiene · 2026
Background

Ocular tuberculosis (tuberculosis) presents with diverse clinical manifestations and remains a diagnostic and therapeutic challenge, particularly in tuberculosis-endemic regions.

Purpose

This case series aimed to describe the clinical manifestations of presumed ocular tuberculosis and to assess the burden of antitubercular therapy-induced optic neuropathy during the study duration.

Results

high-dose tuberculosis drugs damaged the optic nerve, harming vision, in this many patients

TB-associated optic ne
13patien
ATT-induced optic neur
26patien
More results

granulomatous uveitis (n = 2), panuveitis (n = 3), phlyctenular conjunctivitis (n = 1), serpiginous-like choroiditis (n = 3), multifocal choroiditis (n = 4), choroidal granuloma (n = 5), choroidal tubercle (n = 3), and Eales disease (n = 4).

Tuberculosis-associated optic neuropathy was observed in 13 patients secondary to intracranial tuberculosis.

More results

Retrobulbar optic neuritis was more frequently observed than papillitis in these cases.

To conclude, ocular tuberculosis demonstrates varied clinical manifestations, with significant risk of vision loss due to both disease and treatment-related toxicity.

“
Conclusion

Early diagnosis, prompt initiation of antitubercular therapy, and routine ophthalmic monitoring during therapy are essential to reduce visual morbidity in tuberculosis-endemic settings.

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