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Cohort studyJournal of personalized medicine · 2026

Toward Personalized Medicine: The Utility of Enthesis and Joint Ultrasound Examination in Defining the Phenotype of Patients with Acute Anterior Uveitis.

Giorgia Citriniti, Filippo Crescentini, Niccolò Possemato … Pierluigi Macchioni

OphthalmologyCohort study

Active enthesitis on ultrasound was more common in non-granulomatous than granulomatous acute uveitis.

Toward Personalized Medicine: The Utility of Enthesis and Joint Ultrasound Examination in Defining the Phenotype of Patients with Acute Anterior Uveitis.

Giorgia Citriniti … Pierluigi Macchioni

Journal of personalized medicine · 2026

Background

Only one previous study investigated ultrasonographic (ultrasonographic) changes at peripheral entheses and joints in patients with acute anterior uveitis (acute anterior uveitis) and no study has used these data in recognizing unknown spondyloarthropathy as defined by ASAS criteria.

Purpose

The objective of this study was to investigate the prevalence of ultrasonographic enthesis and joint abnormalities in a consecutive series of granulomatous uveitis and non-granulomatous patients and to use these data in recognizing unknown spondyloarthropathy as defined by ASAS criteria.

Methods

A total of 152 consecutive patients diagnosed with acute anterior uveitis [103 non-granulomatous (42 B27-, 61 B27+) and 49 granulomatous uveitis] from the Immunology Eye Unit (AUSL-IRCCS Reggio Emilia, Italy) were enrolled in this study.

n = 29 patients

23%

Results

23%

vs. 8.2%

active tendon/ligament inflammation on ultrasound was more common in non-granulomatous uveitis

n = 29 patients

“

Conclusion · 1 of 2

Acute entheseal lesions and erosions are associated with non-granulomatous, without apparent influence of HLA-B27 positivity.

Conclusion · 2 of 2

ultrasonographic examination helps to recognize previously unknown spondyloarthropathy and to define the disease phenotype of patients, moving toward more personalized treatment.

Post

Toward Personalized Medicine: The Utility of Enthesis and Joint Ultrasound Examination in Defining the Phenotype of Patients with Acute Anterior Uveitis.

Active enthesitis on ultrasound was more common in non-granulomatous than granulomatous acute uveitis.

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