Research on animal models of chronic dacryocystitis in dogs.
Combined nasolacrimal duct cauterization and bacterial inoculation successfully modeled canine dacryocystitis.
Research on animal models of chronic dacryocystitis in dogs.
To explore an ideal animal model of chronic dacryocystitis.
(1) The anatomical structure of the lacrimal drainage system in dogs was observed; (2) The canine lacrimal drainage system was obstructed by cauterization of the nasolacrimal duct; (3) A canine model of dacryocystitis was established by combining nasolacrimal duct cauterization with inoculation of Staphylococcus aureus.
Compared with inoculation of Staphylococcus aureus one week after nasolacrimal duct cauterization, the combined method of nasolacrimal duct cauterization and immediate inoculation of Staphylococcus aureus induced clinical manifestations of dacryocystitis more rapidly in dogs.
Our experimental data demonstrate that the anatomical structure of the canine lacrimal duct is similar to that of humans, providing a solid anatomical foundation for modeling chronic dacryocystitis.
The method of nasolacrimal duct cauterization combined with Staphylococcus aureus injection can rapidly and effectively induce canine dacryocystitis manifestations while being simple and feasible to perform.
Therefore, dogs can be considered as a suitable animal model for further research on chronic dacryocystitis.