Role of Menopausal Hormone Therapy on Strabismus, Strabismus Surgery, and Reoperation Rates.

Cohort studyAmerican journal of ophthalmology· Jul 2026

Role of Menopausal Hormone Therapy on Strabismus, Strabismus Surgery, and Reoperation Rates.

Akshara R Legala, Takashi Nishida, Ashley Liang … Jolene C Rudell

Read paper

Pediatric OphthalmologyCohort studyQ1IF 4.2

Menopausal hormone therapy linked to higher risk of strabismus surgery.

Role of Menopausal Hormone Therapy on Strabismus, Strabismus Surgery, and Reoperation Rates.

Akshara R Legala … Jolene C Rudell

American journal of ophthalmology · Jul 2026 · Q1 in Ophthalmology

Purpose

To evaluate the association between menopausal hormone therapy (menopausal hormone therapy) and strabismus outcomes in menopausal women.

Methods

Female patients in Epic Cosmos with a first menopause diagnosis between ages 44 and 60 years from January 1, 2010, to October 31, 2025 were included.

Results

hormone therapy users had higher odds of needing eye-alignment surgery

HR by subgroup · 95% CI

More results

Among 2,154,255 menopausal patients, 197,576 (9.2%) received menopausal hormone therapy and 1,956,679 (90.8%) did not.

Mean age at menopause diagnosis was 54.9 (4.1) years, and 67.3% identified as White.

“

Conclusion

Menopausal hormone therapy was associated with increased risk of strabismus diagnosis and surgery in menopausal women, suggesting a potential relationship between menopausal hormone therapy and ocular alignment outcomes.

Role of Menopausal Hormone Therapy on Strabismus, Strabismus Surgery, and Reoperation Rates.

Role of Menopausal Hormone Therapy on Strabismus, Strabismus Surgery, and Reoperation Rates.

Related papers