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Cohort studyJournal of clinical practice and research · 2026

Comparison of Success Rates Between Laser Photocoagulation and Intravitreal Anti-Vascular Endothelial Growth Factor Injection for the Treatment of Retinopathy of Prematurity in a Tertiary Referral Center: An 11-Year Survey.

Osman Ahmet Polat, Hidayet Sener, Cagatay Karaca … Cem Evereklioglu

OphthalmologyCohort study

Anti-VEGF injection for retinopathy of prematurity linked to higher reactivation risk than laser

Comparison of Success Rates Between Laser Photocoagulation and Intravitreal Anti-Vascular Endothelial Growth Factor Injection for the Treatment of Retinopathy of Prematurity in a Tertiary Referral Center: An 11-Year Survey.

Osman Ahmet Polat … Cem Evereklioglu

Journal of clinical practice and research · 2026

Purpose

To compare the success and reactivation rates between laser photocoagulation and intravitreal anti-VEGF injection for the treatment of retinopathy of prematurity (retinopathy of prematurity).

Methods

A total of 434 patients with retinopathy of prematurity were included in the study, with 299 treated with laser photocoagulation (group 1) and 135 treated with intravitreal anti-VEGF injection (group 2).

n = 434 patients

Results

anti-VEGF nearly quadrupled the chance retinopathy of prematurity came back after treatment

Laser photocoagulation

3.7%

Anti-VEGF injection

12.6%

More results

The overall reactivation rate for retinopathy of prematurity after treatment was 6.5% (n=28).

The reactivation rates for group 1 and group 2 were 3.7% (n=11) and 12.6% (n=17), respectively, with the difference being significant (p<0.001).

More results

Low birth weight, low gestational age, and aggressive posterior retinopathy of prematurity were identified as factors contributing to an elevated risk of reactivation.

The median time to reactivation was similar for both group 1 and group 2 patients (p>0.05).

“

Conclusion

Both laser application and anti-VEGF injection were effective for the treatment of retinopathy of prematurity. However, initial laser photocoagulation has a lower reactivation rate.

Post

Comparison of Success Rates Between Laser Photocoagulation and Intravitreal Anti-Vascular Endothelial Growth Factor Injection for the Treatment of Retinopathy of Prematurity in a Tertiary Referral Center: An 11-Year Survey.

Anti-VEGF injection for retinopathy of prematurity linked to higher reactivation risk than laser

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