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New research · Ophthalmology
American journal of ophthalmology case reports · 2d
StudyAmerican journal of ophthalmology case reports · 2026

Bilateral lens subluxation in a patient with homocystinuria: a case report.

Zongyi Zhan, Jiachun Cai, Jiaming Wang … Dahui Ma
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OphthalmologyStudy

Lens-fixation surgery restored normal vision in homocystinuria-related lens dislocation.

Bilateral lens subluxation in a patient with homocystinuria: a case report.

Zongyi Zhan … Dahui Ma
American journal of ophthalmology case reports · 2026
Purpose

To report a case of bilateral lens subluxation associated with homocystinuria that had been previously misdiagnosed with high myopia, amblyopia, and keratoconus.

20/20
Results
20/20
corrected vision fully to normal after surgery
More results

OBSERVATIONS: A 19-year-old Asian female presented with progressive bilateral visual decline and hand tremors over 10 years.

Surgical intervention was undertaken to improve visual acuity.

Anterior segment imaging documented bilateral lens subluxation and microspherophakia before and after intraocular lens suture fixation surgery.

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Conclusion

This case demonstrates the importance of basic slit-lamp examination especially after cycloplegic refraction for unusual myopia progression and the need to recognize associated systemic symptoms in ophthalmic practice.

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