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Cohort studyIndian journal of ophthalmology · 2026

Increased neuro-ophthalmic manifestations of herpes zoster infection incidence: A 14-year cohort study from a tertiary medical center.

Ella Nissan, Eden Abergel, Iris Ben Bassat Mizrachi, Ruth Huna-Baron

OphthalmologyCohort study

Neuro-ophthalmic complications of shingles tripled in incidence over 14 years.

Increased neuro-ophthalmic manifestations of herpes zoster infection incidence: A 14-year cohort study from a tertiary medical center.

Ella Nissan … Ruth Huna-Baron

Indian journal of ophthalmology · 2026

Purpose

This study aimed to evaluate the spectrum and incidence of neuro-ophthalmic complications of herpes zoster (herpes zoster) over 14 years at a large tertiary medical center.

Methods

Retrospective cohort study.

Results

checked cases at eye clinics were flagged for these nerve complications, up from before

2006-2012

0.1%

2013-2020

0.3%

More results

The mean age at presentation was 67 years, and 76% were male.

Autoimmune disease was present in 35% of patients, malignant disease in 29%, and 24% were receiving immunosuppressive therapy at herpes zoster onset.

Neuro-ophthalmic manifestations included visual field defect (53%), diplopia (53%), ptosis (47%), and post-herpetic neuralgia (41%).

More results

At the end of follow-up, 18% achieved complete recovery, 65% partial improvement, and 12% showed no improvement.

“

Conclusion · 1 of 2

Neuro-ophthalmic manifestations of herpes zoster appear to be increasing, predominantly affect older males, and frequently result in incomplete recovery. Limited neuroimaging findings highlight the primacy of clinical assessment.

Conclusion · 2 of 2

Larger prospective studies are needed to clarify risk factors and improve management.

Post

Increased neuro-ophthalmic manifestations of herpes zoster infection incidence: A 14-year cohort study from a tertiary medical center.

Neuro-ophthalmic complications of shingles tripled in incidence over 14 years.

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