A Framework for Standardized Manual Segmentation and Measurement of Uveal Melanoma on Ultrasound.

The consensus protocol identified 4 consistent anatomical boundaries: inner retina, inner tumor margin, outer tumor margin, and outer sclera.

Most disagreement occurred at the scleral interface and in cases with shadowing, artifact, subretinal fluid, or mushroom shape.

Derived tumor measurements demonstrated low mean absolute errors of 0.21 mm, 0.59 mm, and 0.72 mm for thickness, 1-chord largest basal diameter, and arc-length largest basal diameter, respectively.