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Cohort studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026

Effect of cataracts on systemic factor prediction from fundus images.

Ryoh Funatsu, Naohisa Mihara, Shoki Miyake … Hiroto Terasaki

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OphthalmologyCohort study

Retinal age estimated from fundus photos drops sharply after cataract surgery.

Effect of cataracts on systemic factor prediction from fundus images.

Ryoh Funatsu … Hiroto Terasaki

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026

Purpose

To evaluate the effect of cataracts on systemic factor predictions from fundus images by comparing predictive values before and after cataract surgery.

Methods

This Retrospective study includes consecutive patients who underwent cataract surgery between January 2024 and July 2024 at Kagoshima University Hospital.

n = 128,000 images

Results

Predicted retinal age fell from 72.1 to 64.5 years after cataract removal.

Preoperative retinal a

72.1years

Postoperative retinal

64.5years

More results

We included 67 patients (101 eyes; 37.3% male) with a mean age of 72.5 ± 11.4 years.

More than half of the participants were receiving treatment for hypertension, diabetes mellitus, or were using steroids.

More results

Among all analyses, only chronological age was significantly associated with retinal age, both preoperatively (β = 0.48, P = 8.6 × 10 - 8 ) and postoperatively (β = 0.47, P = 3.1 × 10 - 9 ).

These findings remained consistent in a subgroup analysis of patients without fundus diseases who underwent only cataract surgery (P = 3.8 × 10 - 10 ).

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Conclusion

Our findings demonstrate that retinal age reflects not only the status of the retina and optic disc but also the presence of coexisting cataracts.

Effect of cataracts on systemic factor prediction from fundus images.

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