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New research · Ophthalmology
Indian journal of medical microbiology · 2d
Cohort studyIndian journal of medical microbiology · 2026

Clinical and Microbiological Profile of Candida Keratitis: A Retrospective Study from South India.

Muralitharan Abirami Priyadharshini, Mary Kiran Danni, Gunasekaran RameshKumar … Prajna Lalitha
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OphthalmologyCohort study

Most Candida keratitis patients had severely reduced vision at presentation.

Clinical and Microbiological Profile of Candida Keratitis: A Retrospective Study from South India.

Muralitharan Abirami Priyadharshini … Prajna Lalitha
Indian journal of medical microbiology · 2026
Background

The incidence is dramatically increasing in tropical regions, especially among patients with prior corneal transplantation, prolonged steroid use and ocular surface disease.

Purpose

To determine the epidemiology, risk factors, management and outcomes of Candida keratitis in South India.

Methods

A retrospective analysis of clinical records of microbiologically confirmed cases of Candida keratitis at a tertiary eye hospital in South India between January 2017 and January 2024 was performed.

88.2%
Results
88.2%
most had vision worse than 5/60 - near-legal blindness at diagnosis
More results

Seventeen cases (median age: 66 years) were identified.

Major risk factors were topical steroid use (41.2%) and corneal transplantation (35.2%), with ocular surface diseases and trauma accounting for 17.6% each, respectively.

More results

Candida parapsilosis was the most commonly isolated species (41.2%), followed by Candida albicans (35.3%), Candida tropicalis (17.6%) and Trichomonascus ciferrii (Candida ciferrii) (5.9%).

Medical management most commonly included topical amphotericin B, itraconazole, natamycin and voriconazole.

“
Conclusion

The rising incidence of Candida keratitis in tropical regions presents a clinical challenge, primarily affecting immunosuppressed patients and those with ocular surgery, requiring prompt intervention to improve outcomes.

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