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New research · Ophthalmology
Frontiers in medicine · 2d
Cohort studyFrontiers in medicine · 2026

Two-year outcomes of trabeculo-canalectomy for glaucoma secondary to iridocorneal endothelial syndrome: a retrospective study.

Zhan Xie, Haiyue Xie, Yangyang Lu … Hong Sun
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OphthalmologyCohort study

Trabeculo-canalectomy achieved complete surgical success in most eyes with this glaucoma at 2 years.

Two-year outcomes of trabeculo-canalectomy for glaucoma secondary to iridocorneal endothelial syndrome: a retrospective study.

Zhan Xie … Hong Sun
Frontiers in medicine · 2026
Background

The study aimed to evaluate the 2-year outcomes of a new surgical procedure for treating Chinese patients with glaucoma secondary to iridocorneal endothelial syndrome (GS-ICE).

Purpose

The study aimed to evaluate the 2-year outcomes of a new surgical procedure for treating Chinese patients with glaucoma secondary to iridocorneal endothelial syndrome (GS-ICE).

Methods

This was a retrospective study involving 26 GS-ICE patients (26 eyes) surgically treated with trabeculo-canalectomy in the First Affiliated Hospital with Nanjing Medical University from January 2015 to June 2024, and postoperatively followed up for 2 years.

n = 26 eyes
Results

80.8% had eye pressure controlled without needing any glaucoma medication at 2 years.

80.8%
Complete success
11.5%
Conditional success
More results

A total of 26 GS-ICE patients (26 eyes) with an average age of 48.58 ± 9.61 (27-67) years and a median number of 2 (0-4) anti-glaucoma medication regimens were retrospectively included.

More results

Compared to the preoperative value (31.10 ± 11.00 mmHg), the postoperative mean IOP was significantly lower, reaching 13.27 ± 2.68, 15.00 ± 3.77, 15.04 ± 2.81, 16.27 ± 3.03, 16.96 ± 3.12, and 16.89 ± 3.18 mmHg at 1 week, 1 month, 3 months, 6 months, 1 year, and 2 years, respectively ( p < 0.001).

“
Conclusion

Trabeculo-canalectomy brings favorable two-year outcomes among GS-ICE patients, including an effective IOP control, a reduction of anti-glaucoma medications, and a low risk of postoperative complications.

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