Longitudinal Change in Keratoconjunctivitis Sicca by Sjögren's Disease Status.

This analysis included data from 427 participants (mean age: 54.4±12.8 years, 94.8% female), including 305 with KCS+SjD and 122 with KCS-only.

Similarly, participants with KCS+SjD demonstrated greater longitudinal decline in tear break-up time (-1.10 sec, 95% CI: -1.56 to -0.65; P <.001) and in Schirmer I (-2.16 mm, 95% CI: -3.31 to -1.01; P <.001).

The difference in OSDI-6 scores was not statistically significant (0.36, 95% CI, -0.60 to 1.33; P = .46).