Effects of Sitagliptin and Celery Seed Extract on Corneal Nerve Morphology and Sensory Dysfunction in Diabetic Rats.
Sitagliptin and celery seed extract restored corneal nerve fiber length in diabetic rats.
Effects of Sitagliptin and Celery Seed Extract on Corneal Nerve Morphology and Sensory Dysfunction in Diabetic Rats.
Diabetic peripheral neuropathy (diabetic peripheral neuropathy) is a common complication of diabetes, characterised by sensory dysfunction and progressive loss of small nerve fibres.
The present study aimed to investigate the effects of sitagliptin and celery seed extract on corneal nerve morphology, corneal sensitivity, and sensory behaviour in a high-fat diet, streptozotocin-induced rat model of type 2 diabetes.
Male Sprague Dawley rats ( n = 24) were used to induce type 2 diabetes by combining a high-fat diet with streptozotocin.
Tortuosity was significantly decreased in both the sitagliptin (4.3 ± 0.1) and celery seed extract (4.9 ± 0.1) groups compared with the untreated diabetic group.
This was rescued with sitagliptin and celery seed extract treatment (5.5 ± 0.1 and 5.3 ± 0.1 cm, respectively; p < 0.05).
Treatment with sitagliptin and celery seed extract significantly reversed these changes, as evidenced by increased withdrawal latency in the cold-water test and decreased response time in the acetone drop test.
However, this improvement was not significant in the hot-water test.
Sitagliptin and celery seed extract restored corneal nerve architecture, corneal sensitivity, and sensory dysfunction in diabetic rats, suggesting the therapeutic potential for diabetic peripheral neuropathy.