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New research · Ophthalmology
Nephron · 2d
Cohort studyNephron · 2026

Elevated Intraocular Pressure Independently Predicts Long-Term Progression to Advanced Chronic Kidney Disease: A 20-Year Longitudinal Cohort Study.

Riri Oh, Jun Ogino, Yukie Sakuma … Naotake Hashimoto
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OphthalmologyCohort study

Higher eye pressure was linked to greater risk of advanced kidney disease progression.

Elevated Intraocular Pressure Independently Predicts Long-Term Progression to Advanced Chronic Kidney Disease: A 20-Year Longitudinal Cohort Study.

Riri Oh … Naotake Hashimoto
Nephron · 2026
Background

Glaucoma is the leading cause of irreversible blindness worldwide, and chronic kidney disease (chronic kidney disease) is associated with progression to end-stage renal disease, cardiovascular events, and increased mortality.

Purpose

We investigated whether elevated IOP is associated with advanced chronic kidney disease progression in a long-term observational cohort.

Methods

A total of 4,170 participants who visited a preventive medicine research center were followed for up to 20 years.

n = 4,170 participants
Results

higher eye pressure meant greater risk of severe kidney function decline

HR by subgroup · 95% CI
null = 1
5 mmHg
1.49
consistent in the propensity
1.56
More results

The annual decline in eGFR associated with higher baseline IOP was -0.939 mL/min/year, based on ROC-derived risk stratification.

Multivariable Fine-Gray analysis identified IOP ≥17.5 mmHg as an independent risk factor for advanced chronic kidney disease, together with older age, obesity, diabetes, and proteinuria.

More results

These findings were consistent in the propensity score-matched cohort (HR 1.56; 95% CI: 1.01-2.39; p = 0.043).

“
Conclusion · 1 of 2

Elevated intraocular pressure is independently associated with progression to advanced chronic kidney disease.

Conclusion · 2 of 2

Incorporating IOP into conventional risk assessment may improve identification of individuals at high risk for chronic kidney disease progression.

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