Short-Term Intraocular Pressure Changes After Intravitreal Aflibercept 8 mg via Prefilled Syringe.

Cohort studyOphthalmology and therapy· Jul 2026

Short-Term Intraocular Pressure Changes After Intravitreal Aflibercept 8 mg via Prefilled Syringe.

Arianna Peyla, Matteo Bonanata, Martina Pache … Giulio Volpe

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RetinaCohort studyClinical practiceQ1IF 4.2

Aflibercept 8 mg prefilled syringe injections were linked to a brief, sharp eye-pressure spike.

Short-Term Intraocular Pressure Changes After Intravitreal Aflibercept 8 mg via Prefilled Syringe.

Arianna Peyla … Giulio Volpe

Ophthalmology and therapy · Jul 2026 · Q1 in Ophthalmology

Background

Intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is a standard treatment for neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (diabetic macular oedema).

Purpose

The aim of this study was to assess short-term IOP changes after intravitreal aflibercept 8 mg administered via PFS and to compare these results with historical cohorts receiving aflibercept 8 mg via standard syringe and aflibercept 2 mg via PFS.

Methods

With glaucoma or ocular hypertension were excluded.

Results

Eye pressure jumped from ~14 to about 51 mmHg 30 seconds after injection, then fell.

Baseline

13.92mmHg

30 s

51.29mmHg

5 min

31.32mmHg

15 min

20.25mmHg

More results

Baseline IOP was similar across the three groups (p = 0.54).

No statistically significant between-group differences were detected at any timepoint (all p ≥ 0.18).

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Conclusion · 1 of 2

Intravitreal aflibercept 8 mg administered via PFS was associated with a transient rise in IOP immediately after injection, which resolved within 15 min and was similar to that observed with aflibercept 2 mg via PFS and aflibercept 8 mg via standard syringe.

Conclusion · 2 of 2

These findings contribute to the characterization of the short-term IOP response associated with aflibercept 8 mg PFS administration and may help inform routine clinical practice.

Short-Term Intraocular Pressure Changes After Intravitreal Aflibercept 8 mg via Prefilled Syringe.

Short-Term Intraocular Pressure Changes After Intravitreal Aflibercept 8 mg via Prefilled Syringe.

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