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New research · Ophthalmology
Korean journal of ophthalmology : KJO · 2d
Cohort studyKorean journal of ophthalmology : KJO · 2026

Clinical Outcomes of 50% Autologous Serum Eye Drops for Contact Lens-Induced Limbal Stem Cell Deficiency: A Staging-Based Evaluation.

Jae-Jung Kim, Joo-Ye Park, Ji-Yun Song … So-Hyang Chung
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OphthalmologyCohort study

Autologous serum eye drops linked to improved limbal stem cell deficiency stage in contact lens wearers

Clinical Outcomes of 50% Autologous Serum Eye Drops for Contact Lens-Induced Limbal Stem Cell Deficiency: A Staging-Based Evaluation.

Jae-Jung Kim … So-Hyang Chung
Korean journal of ophthalmology : KJO · 2026
Purpose

To evaluate the clinical outcomes of treatment including 50% autologous serum eye drops in patients with contact lens-induced limbal stem cell deficiency (limbal stem cell deficiency) using consensus-based staging.

Methods

This retrospective study included 14 eyes of 11 patients with contact lens-induced limbal stem cell deficiency treated with 50% autologous serum eye drops between 2017 and 2025.

n = 14 eyes
76.9%
Results
76.9%
improvement seen in most treated eyes, with no cases getting worse
n = 14 eyes
More results

The severity of corneal epithelial defect (corneal epithelial defect) and corneal neovascularization (neovascularization) significantly decreased after treatment (p < 0.05, respectively), and corneal opacity showed a decreasing trend without statistical significance.

More results

At 3 months, BCVA improved in 64.3% of eyes, with the mean value decreasing significantly from 0.65± 0.41 to 0.51 ± 0.46 logMAR (mean change: -0.14 ± 0.22; p = 0.032).

“
Conclusion · 1 of 2

Treatment including 50% autologous serum eye drops was associated with significant improvements in consensus-based limbal stem cell deficiency stage, epithelial integrity, neovascularization, and visual acuity in patients with contact lens-induced limbal stem cell deficiency.

Conclusion · 2 of 2

These findings contribute additional evidence supporting conservative management for contact lens-induced limbal stem cell deficiency.

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