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Cohort studyJournal of clinical medicine · 2026

Clinical Predictors and Recovery Patterns of Visual Impairment as a Post-Stroke Complication: A Retrospective Single-Center Cohort Study from a Romanian Comprehensive Stroke Unit.

Mirela Loredana Grigoraș, Sorin Lucian Bolintineanu, Livia Stanga, Laura Andreea Ghenciu

OphthalmologyCohort study

Combining clinical, imaging, and eye-scan data strongly predicted stroke visual recovery.

Clinical Predictors and Recovery Patterns of Visual Impairment as a Post-Stroke Complication: A Retrospective Single-Center Cohort Study from a Romanian Comprehensive Stroke Unit.

Mirela Loredana Grigoraș … Laura Andreea Ghenciu

Journal of clinical medicine · 2026

Background

Visual impairment is an underrecognized but functionally disabling complication of stroke that adversely affects rehabilitation potential, autonomy, and quality of life.

Purpose

This study aimed to identify clinical, imaging, and ophthalmologic predictors of favorable visual recovery and to evaluate whether integrating these domains improves early prognostic stratification beyond standard neurological assessment.

Methods

We conducted a retrospective single-center cohort study of 71 consecutive adult patients admitted with acute stroke and a documented visual complication between January 2022 and September 2025 at Pius Brinzeu Emergency County Hospital and Victor Babes University of Medicine and Pharmacy Timisoara.

n = 71 patients

AUC of 0.87

Results

AUC of 0.87

combining these factors predicted recovery accurately, far better than chance

n = 71 patients

More results

Twenty-nine patients (40.8%) achieved favorable recovery, while 42 (59.2%) had persistent impairment.

National Institutes of Health Stroke Scale, time to rehabilitation, and optical coherence tomography (optical coherence tomography) RNFL thickness remained independent predictors.

More results

Cluster analysis identified three distinct phenotypes with favorable recovery rates of 79.2%, 34.8%, and 8.3%.

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Conclusion

Combined clinical, neuroimaging, and ophthalmologic profiling-particularly optical coherence tomography RNFL-meaningfully refines early prediction of post-stroke visual recovery and supports phenotype-driven rehabilitation planning.

Clinical Predictors and Recovery Patterns of Visual Impairment as a Post-Stroke Complication: A Retrospective Single-Center Cohort Study from a Romanian Comprehensive Stroke Unit.

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