A hyaluronic acid containing contact lens disinfecting solution can improve contact lens comfort.

Twenty-three participants used hyaluronic acid derivative MPS and eighteen used non-hyaluronic acid derivative MPS.

No significant comfort improvement was observed with non-hyaluronic acid derivative MPS (P ≤ 0.13; mean reduction ≤3.3).

These symptom improvements were generally not accompanied by significant changes in tear stability, tear volume, lipid layer thickness, or ocular staining.