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New research · Ophthalmology
Contact lens & anterior eye : the journal of the British Contact Lens Association · 3d
StudyContact lens & anterior eye : the journal of the British Contact Lens Association · 2026

A hyaluronic acid containing contact lens disinfecting solution can improve contact lens comfort.

Motohiro Itoi, Shyam Tummanapalli, Mark Willcox
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OphthalmologyStudy

Hyaluronic acid disinfecting solution improved contact lens comfort symptoms significantly

A hyaluronic acid containing contact lens disinfecting solution can improve contact lens comfort.

Motohiro Itoi … Mark Willcox
Contact lens & anterior eye : the journal of the British Contact Lens Association · 2026
Purpose

To evaluate the effect of a low-molecular weight hyaluronic acid derivative (hyaluronic acid derivative), incorporated into a multipurpose disinfecting solution (MPS), on symptoms and signs of comfort during contact lens wear.

Methods

Wore comfilcon A contact lenses and used cleadew MPS with or without hyaluronic acid derivative for eight weeks, with monthly lens replacement.

Results

in weeks of daily discomfort, symptom scores dropped this many points

HAD MPS
7.7points
non-HAD MPS
3.3points
More results

Twenty-three participants used hyaluronic acid derivative MPS and eighteen used non-hyaluronic acid derivative MPS.

No significant comfort improvement was observed with non-hyaluronic acid derivative MPS (P ≤ 0.13; mean reduction ≤3.3).

More results

These symptom improvements were generally not accompanied by significant changes in tear stability, tear volume, lipid layer thickness, or ocular staining.

“
Conclusion · 1 of 2

Hyaluronic acid derivative-containing MPS improves contact lens comfort, including in previously symptomatic daily disposable lens wearers.

Conclusion · 2 of 2

This benefit may relate to improved lens surface wettability and reduced friction, warranting further investigation.

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