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New research · Ophthalmology
Drug delivery and translational research · 3d
Animal / preclinicalDrug delivery and translational research · 2026

Temperature and osmotic pressure dual-stimuli-responsive ophthalmic gels embedded with HPCD-modified nanoparticles for prolonged-release delivery of natamycin.

Bixia Lin, Fangfei Fan, Hui Xu … Lirong Niu
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OphthalmologyAnimal / preclinical

New nanoparticle eye-drop formulation boosted corneal penetration of an antifungal drug nearly 3-fold in lab tests.

Temperature and osmotic pressure dual-stimuli-responsive ophthalmic gels embedded with HPCD-modified nanoparticles for prolonged-release delivery of natamycin.

Bixia Lin … Lirong Niu
Drug delivery and translational research · 2026
Background

Fungal keratitis (fungal keratitis) is a severe ocular disease that may cause blindness in severe cases.

Results
2.89-fold
the drug soaked into the cornea nearly 3 times faster/deeper than the standard drop
More results

However, natamycin bioavailability is less than 2% due to special environment of the eye.

As a result, the nanoparticles with a hydrophilic membrane (F2) demonstrated more superior stability than the plain nanoparticle (F1).

Subsequently, F2 was incorporated into a temperature- and osmolarity dual-responsive ophthalmic gel (Tem-Osm gel).

More results

Moreover, the in vitro antifungal experiments demonstrated that F2 and Tem-Osm gel exhibited more superior antifungal activity, lower MIC/EC50 values and larger inhibition zones than the natamycin suspension.

“
Conclusion

Overall, the study indicates that the novel combination of nanoparticle and multi-responsive ocular gel sustained-release delivery system holds promising potential as a therapeutic approach for fungal keratitis.

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