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New research · Ophthalmology
Ophthalmology science · 3d
Cross-sectionalOphthalmology science · 2026

Comparative Diagnostic Efficacy of Swept-Source OCT and Scheimpflug Imaging in Clinically Unaffected Eyes of Very Asymmetric Ectasia.

Robert Herber, Tadas Naujokaitis, Renato Ambrósio … Ramin Khoramnia
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OphthalmologyCross-sectional

A new OCT-based index best detects early ectasia risk in eyes with no visible signs

Comparative Diagnostic Efficacy of Swept-Source OCT and Scheimpflug Imaging in Clinically Unaffected Eyes of Very Asymmetric Ectasia.

Robert Herber … Ramin Khoramnia
Ophthalmology science · 2026
Purpose

To determine the diagnostic ability of corneal tomography indices for detecting corneal ectasia using a swept-source OCT system (SS-OCT; ANTERION), a rotating Scheimpflug camera system (Pentacam HR), and a dynamic ultra-high-speed Scheimpflug noncontact tonometry and cornea analyzer (Corvis ST).

Methods

A prospective cross-sectional study.

n = 228
Results

higher score means a stronger, earlier warning sign even in normal-looking eyes

SCORE
0.888AUC
TBI
0.847AUC
PRFI
0.765AUC
BAD-D
0.686AUC
More results

Sensitivity and specificity were 75% and 85% for Screening Corneal Objective Risk of Ectasia, 58%/86% for pentacam random forest index, 41%/90% for BAD-D, and 77%/81% for TBI, respectively.

More results

In distinguishing healthy eyes from all ectatic eyes, AUC values were 0.978 for Screening Corneal Objective Risk of Ectasia, 0.955 for pentacam random forest index, and 0.936 for BAD-D (all P < 0.001).

Tomographical and biomechanical index (AUC 0.968) and Screening Corneal Objective Risk of Ectasia were comparable ( P = 0.06).

“
Conclusion · 1 of 2

Screening Corneal Objective Risk of Ectasia derived from SS-OCT and TBI from integrated Scheimpflug imaging demonstrated the highest and comparable diagnostic performance for detecting clinically unaffected fellow eyes without clinical ectasia signs but with ectasia susceptibility (VAE-NES).

Conclusion · 2 of 2

FINANCIAL

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