Bilateral Iris Metastasis of Small Cell Lung Carcinoma: A Case Report and Systematic Review.
Iris metastasis from small cell lung carcinoma carries poor survival
Bilateral Iris Metastasis of Small Cell Lung Carcinoma: A Case Report and Systematic Review.
To report a rare case of bilateral iris metastasis from small cell lung carcinoma (small cell lung carcinoma) and systematically review the literature on small cell lung carcinoma-associated iris metastases, with emphasis on clinical presentation, management, and outcomes.
Results (Systematic Review): Seventeen studies comprising 17 patients were included; the median age was 60 years, and 64.7% were male.
PubMed, ScienceDirect, Scopus, and Web of Science were comprehensively searched on 10 July 2025.
Case report: A 58-year-old woman with previously treated small cell lung carcinoma developed bilateral iris metastases one year after complete remission of the primary tumor.
The median interval from small cell lung carcinoma diagnosis to ocular presentation was 4 months, although iris metastasis was occasionally the initial or concurrent manifestation of disease.
Bilateral iris metastasis from small cell lung carcinoma is rare and may occur as a manifestation of recurrent disease after remission.
It is an aggressive condition characterized by nonspecific ocular symptoms, variable management, and poor survival, underscoring the importance of early recognition and the need for evidence-based diagnostic and therapeutic strategies.