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StudyPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026

Comparison of model-based and delineation-based target volume definition for ocular proton therapy.

Lisa Klaassen, Coen R N Rasch, Jan-Willem M Beenakker

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OphthalmologyStudy

Model-based tumor contouring overestimates delineated uveal melanoma volume to ensure coverage.

Comparison of model-based and delineation-based target volume definition for ocular proton therapy.

Lisa Klaassen … Jan-Willem M Beenakker

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026

Background

In recent years, eye-specific, high-resolution MRI protocols have become available for ocular tumours, enabling 3D tumour delineation.

Methods

Tumours were delineated for 70 uveal melanoma patients.

n = 70 patients

Results

at that coverage level, contouring added extra tumor volume beyond the true tumor

16.4%

Irregularly shaped

36.6%

Dome-shaped

More results

For 69/70 patients, an acceptable tumour model could be generated, out of whom 12/69 needed an expansion of the tumour base or added tumour thickness to produce at least one acceptable model.

Irregularly shaped tumours showed larger overestimations than dome-shaped tumours (16.4% vs 36.6%, p < 0.001).

“

Conclusion

Tumour models as used in ocular proton therapy treatment planning systems can achieve acceptable tumour coverage. However, to achieve this coverage, the tumour models overestimated the delineated tumour volume.

Post

Comparison of model-based and delineation-based target volume definition for ocular proton therapy.

Model-based tumor contouring overestimates delineated uveal melanoma volume to ensure coverage.

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