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New research · Ophthalmology
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 4d
StudyPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026

Comparison of model-based and delineation-based target volume definition for ocular proton therapy.

Lisa Klaassen, Coen R N Rasch, Jan-Willem M Beenakker
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OphthalmologyStudy

Model-based tumor contouring overestimates delineated uveal melanoma volume to ensure coverage.

Comparison of model-based and delineation-based target volume definition for ocular proton therapy.

Lisa Klaassen … Jan-Willem M Beenakker
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026
Background

In recent years, eye-specific, high-resolution MRI protocols have become available for ocular tumours, enabling 3D tumour delineation.

Methods

Tumours were delineated for 70 uveal melanoma patients.

n = 70 patients
Results

at that coverage level, contouring added extra tumor volume beyond the true tumor

16.4%
Irregularly shaped
36.6%
Dome-shaped
More results

For 69/70 patients, an acceptable tumour model could be generated, out of whom 12/69 needed an expansion of the tumour base or added tumour thickness to produce at least one acceptable model.

Irregularly shaped tumours showed larger overestimations than dome-shaped tumours (16.4% vs 36.6%, p < 0.001).

“
Conclusion

Tumour models as used in ocular proton therapy treatment planning systems can achieve acceptable tumour coverage. However, to achieve this coverage, the tumour models overestimated the delineated tumour volume.

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