Fractionated stereotactic re-irradiation after plaque radiotherapy (brachytherapy) failure in uveal melanoma.

Cohort studyJournal of contemporary brachytherapy· Jun 2026

Fractionated stereotactic re-irradiation after plaque radiotherapy (brachytherapy) failure in uveal melanoma.

Adam Deja, Patrycja Pijanka-Maciaszczyk, Piotr Milecki, Iwona Rospond-Kubiak

Read paper

Ocular OncologyCohort studyTreatmentQ3IF 1.4

Salvage radiotherapy preserved the eye in most recurrent uveal melanoma cases after brachytherapy failure

Fractionated stereotactic re-irradiation after plaque radiotherapy (brachytherapy) failure in uveal melanoma.

Adam Deja … Iwona Rospond-Kubiak

Journal of contemporary brachytherapy · Jun 2026

Background

Local recurrence after ruthenium-106 ( 106 Ru) interventional radiotherapy (interventional radiotherapy) for uveal melanoma remains a therapeutic challenge.

Purpose

This study aimed to evaluate the efficacy and safety of fractionated stereotactic radiotherapy (fSRT) used as a salvage, globe-preserving option after failed interventional radiotherapy.

Methods

With locally recurrent uveal melanoma previously treated with 106 Ru brachytherapy were retrospectively analyzed.

Results

78%

most patients kept their eye without needing full eye removal

More results

Nine patients were identified.

The most frequent toxicity was cataract (55.6%); no secondary glaucoma or distant metastases were observed.

“

Conclusion · 1 of 2

Salvage treatment with fSRT after 106 Ru interventional radiotherapy failure provides excellent local control with acceptable toxicity.

Conclusion · 2 of 2

This approach represents an effective, non-invasive alternative to enucleation in selected patients with recurrent uveal melanoma.

Fractionated stereotactic re-irradiation after plaque radiotherapy (brachytherapy) failure in uveal melanoma.

Fractionated stereotactic re-irradiation after plaque radiotherapy (brachytherapy) failure in uveal melanoma.

Related papers