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New research · Ophthalmology
Journal of contemporary brachytherapy · 4d
Cohort studyJournal of contemporary brachytherapy · 2026

Fractionated stereotactic re-irradiation after plaque radiotherapy (brachytherapy) failure in uveal melanoma.

Adam Deja, Patrycja Pijanka-Maciaszczyk, Piotr Milecki, Iwona Rospond-Kubiak
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OphthalmologyCohort study

Salvage radiotherapy preserved the eye in most recurrent uveal melanoma cases after brachytherapy failure

Fractionated stereotactic re-irradiation after plaque radiotherapy (brachytherapy) failure in uveal melanoma.

Adam Deja … Iwona Rospond-Kubiak
Journal of contemporary brachytherapy · 2026
Background

Local recurrence after ruthenium-106 ( 106 Ru) interventional radiotherapy (interventional radiotherapy) for uveal melanoma remains a therapeutic challenge.

Purpose

This study aimed to evaluate the efficacy and safety of fractionated stereotactic radiotherapy (fSRT) used as a salvage, globe-preserving option after failed interventional radiotherapy.

Methods

With locally recurrent uveal melanoma previously treated with 106 Ru brachytherapy were retrospectively analyzed.

Results
78%
most patients kept their eye without needing full eye removal
More results

Nine patients were identified.

The most frequent toxicity was cataract (55.6%); no secondary glaucoma or distant metastases were observed.

“
Conclusion · 1 of 2

Salvage treatment with fSRT after 106 Ru interventional radiotherapy failure provides excellent local control with acceptable toxicity.

Conclusion · 2 of 2

This approach represents an effective, non-invasive alternative to enucleation in selected patients with recurrent uveal melanoma.

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