Ophthalmic Disease Burden in Adults with Autism Spectrum Disorder.

Cohort studyAmerican journal of ophthalmology· Jul 2026

Ophthalmic Disease Burden in Adults with Autism Spectrum Disorder.

Surya V Pulukuri, Romila Santra, Susannah Rowe, Isdin Oke

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OphthalmologyCohort studyClinical practiceQ1IF 4.2

Adults with autism spectrum disorder had more than twice the odds of any ocular condition.

Ophthalmic Disease Burden in Adults with Autism Spectrum Disorder.

Surya V Pulukuri … Isdin Oke

American journal of ophthalmology · Jul 2026 · Q1 in Ophthalmology

Purpose

To compare the documented prevalence of common treatable ocular conditions among US adults with and without autism spectrum disorder (autism spectrum disorder) in a large, socioeconomically diverse cohort.

Methods

Adults aged 18 years or older in the National Institutes of Health All of Us Research Program database, version 8, with electronic health record data.

n = 1050 adults

Results

having autism roughly doubled the odds of any diagnosed eye problem

OR by subgroup · 95% CI

More results

Among 5250 matched participants, 1050 adults had autism spectrum disorder and 4200 were controls; the cohort had a mean age of 39.1 years and was 49.3% male.

Associations were similar from unadjusted through fully adjusted models.

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Conclusion · 1 of 2

Adults with autism spectrum disorder had higher documented prevalence and odds of multiple treatable ocular conditions when compared to matched adults without autism spectrum disorder.

Conclusion · 2 of 2

Greater attention should be directed toward autism-informed adult eye care, including proactive screening, sensory and communication accommodations, and coordinated follow-up to support timely identification and management of ocular diseases in this population.

Ophthalmic Disease Burden in Adults with Autism Spectrum Disorder.

Ophthalmic Disease Burden in Adults with Autism Spectrum Disorder.

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