Identification of mechanical ventilation-related risk factors for retinopathy of prematurity in preterm infants.
Each extra day on nasal CPAP raised retinopathy of prematurity risk by 4%
Identification of mechanical ventilation-related risk factors for retinopathy of prematurity in preterm infants.
Retinopathy of prematurity (retinopathy of prematurity) remains a leading cause of preventable childhood blindness.
This study investigated whether the mode and duration of respiratory support independently influence retinopathy of prematurity risk.
We conducted a single-center retrospective cohort study of 83 preterm infants (gestational age <28 weeks) admitted to the neonatal intensive care unit (neonatal intensive care unit) at Jeonbuk National University Hospital (2014-2024).
more days on this breathing support raised eye disease risk
Retinopathy of prematurity was diagnosed in 52 infants (62.7%).
In unadjusted analyses, gestational age [odds ratio (OR) =0.54; 95% confidence interval (CI): 0.35-0.80; P<0.001] and nasal continuous positive airway pressure duration (OR =1.04; 95% CI: 1.01-1.09; P=0.01) were significantly associated with retinopathy of prematurity, alongside time-weighted average positive end-expiratory pressure on days 7 and 10.
Nasal continuous positive airway pressure duration is independently associated with retinopathy of prematurity in infants born before 28 weeks, with each additional day associated with a 4% increase in risk after adjustment for gestational age.
This association was independent of mean FiO 2 , suggesting that oxygenation variability during spontaneous breathing may be a more proximal pathophysiological driver; however, as oxygen saturation (SpO 2 ) variability was not directly measured, this interpretation should be regarded as hypothesis-generating.