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Cohort studyIndian journal of ophthalmology · 2026

Observations of simultaneous aggressive anemia correction and intravitreal therapy for aggressive retinopathy of prematurity: A multimodal retinopathy of prematurity assessment study report number 2.

Akash Belenje, Rakasi Ugandhar Reddy, Brijesh Takkar … Subhadra Jalali

OphthalmologyCohort study

Blood transfusion during anti-VEGF therapy was linked to less need for repeat laser treatment

Observations of simultaneous aggressive anemia correction and intravitreal therapy for aggressive retinopathy of prematurity: A multimodal retinopathy of prematurity assessment study report number 2.

Akash Belenje … Subhadra Jalali

Indian journal of ophthalmology · 2026

Purpose

To study the effect of simultaneous aggressive anemia correction and intravitreal anti-vascular endothelial growth factor (anti-VEGF) Bevacizumab in aggressive retinopathy of prematurity (aggressive retinopathy of prematurity) using multimodal imaging biomarkers.

Methods

Noncontact ultra-widefield fundus imaging with integrated UWF-guided swept source optical coherence tomography (swept source optical coherence tomography) was performed prospectively before and after intravitreal anti-VEGF (Bevacizumab) monotherapy.

n = 40 eyes

P value 0.001

Results

P value 0.001

fewer transfused babies needed repeat laser treatment for their eyes

n = 40 eyes

More results

Group 1 eyes showed faster resolution of multilayered hemorrhages ( P value 0.030) and faster vascular progression to zone 3 ( P value 0.004).

Resolution of ischemic OCT biomarkers, resolution of hyperreflectivity of the inner retinal layers, and improvement in choroidal thickness >250 microns were better in Group 1 than in Group 2.

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Conclusion · 1 of 2

Prompt correction of moderate to severe anemia with blood transfusion in anti-VEGF-injected aggressive retinopathy of prematurity eyes resulted in faster resolution of retinal hemorrhages and faster vascular progression to the periphery.

Conclusion · 2 of 2

These eyes showed improved multimodal imaging biomarkers and a lower chance of reactivation or persistent avascular retina needing retreatment with laser.

Post

Observations of simultaneous aggressive anemia correction and intravitreal therapy for aggressive retinopathy of prematurity: A multimodal retinopathy of prematurity assessment study report number 2.

Blood transfusion during anti-VEGF therapy was linked to less need for repeat laser treatment

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