Anterior segment optical coherence tomography angiography in the evaluation of thyroid eye disease: a pilot study.
Vessel density on eye imaging is higher in thyroid eye disease than in healthy eyes
Anterior segment optical coherence tomography angiography in the evaluation of thyroid eye disease: a pilot study.
Current grading systems for thyroid eye disease (thyroid eye disease) are subjective, highlighting the need for objective assessment tools.
This pilot study evaluated whether anterior segment optical coherence tomography angiography (anterior segment optical coherence tomography angiography) can detect characteristic vasculature changes in thyroid eye disease.
A prospective comparative case series at Moorfields Eye Hospital included patients with thyroid eye disease and healthy controls.
vessel coverage in eye tissue was higher with thyroid eye disease than without
Thyroid eye disease patients had higher episcleral/scleral vessel density index than conjunctival epithelium; the inverse was observed in controls.
Active thyroid eye disease (CAS = 3-7) exhibited the highest vessel density index versus inactive thyroid eye disease (CAS = 0-2) and controls.
Fractal dimension was higher in thyroid eye disease, increasing progressively from controls to inactive and active thyroid eye disease.
Four patients (6 eyes) underwent decompression surgery with non-significant reductions in vessel density index and fractal dimension.
Anterior segment optical coherence tomography angiography detects significant differences in vascular parameters between thyroid eye disease and healthy controls, supporting its potential as a non-invasive, quantitative adjunct in thyroid eye disease grading systems.