Retinal neuroaxonal degeneration in NMOSD vs. MS and unaffected controls: A systematic review and… | ScholarDeck

Paper

Retinal neuroaxonal degeneration in NMOSD vs. MS and unaffected controls: A systematic review and meta-analysis of OCT biomarkers.

New research · Ophthalmology

Multiple sclerosis and related disorders · 1mo

ReviewMultiple sclerosis and related disorders· Jul 2026

Retinal neuroaxonal degeneration in NMOSD vs. MS and unaffected controls: A systematic review and meta-analysis of OCT biomarkers.

Bojun Wang, Jiayue Liu, Huiyuan Zhang … Xiang Li

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RetinaReviewDiagnosisQ1IF 2.8

Retinal nerve fiber layer thinning is more severe in neuromyelitis optica spectrum disorder than in multiple sclerosis.

Retinal neuroaxonal degeneration in NMOSD vs. MS and unaffected controls: A systematic review and meta-analysis of OCT biomarkers.

Bojun Wang … Xiang Li

Multiple sclerosis and related disorders · Jul 2026 · Q1 in General Medicine

Background

Neuromyelitis optica spectrum disorder (neuromyelitis optica spectrum disorder) is an autoimmune disease characterized by optic neuritis and myelitis, often misdiagnosed as multiple sclerosis (multiple sclerosis).

Methods

This review is reported according to the Meta-analysis of Observational Studies in Epidemiology guidelines and assessed the risk of bias of the included studies.

Results

WMD = -11.68, p < 0.001

nerve fiber layer around the optic nerve was thinner in neuromyelitis optica spectrum disorder than multiple sclerosis - worse damage

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Conclusion

Optical coherence tomography serves as a validated imaging biomarker for detecting neuromyelitis optica spectrum disorder-specific intraretinal neurodegeneration, delineating pathological mechanisms and enhancing differential diagnosis, prognostication, and therapeutic monitoring.

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