Effects of levofloxacin eye drops on ocular surface bacterial colonization and postoperative infection rate…

Cohort studyPakistan journal of pharmaceutical sciences· Oct 2026

Effects of levofloxacin eye drops on ocular surface bacterial colonization and postoperative infection rate in patients undergoing blepharoplast.

Shu Wang, Guoping Wu, Wenwen Zhang

CorneaCohort studyTreatmentQ3IF 0.7

Levofloxacin eye drops associated with lower postoperative infection rate after blepharoplasty.

Effects of levofloxacin eye drops on ocular surface bacterial colonization and postoperative infection rate in patients undergoing blepharoplast.

Shu Wang … Wenwen Zhang

Pakistan journal of pharmaceutical sciences · Oct 2026

Background

Ocular surface bacterial colonization is a key risk factor for postoperative infection after blepharoplasty, yet clinical evidence on the impact of levofloxacin eye drops remains limited.

Purpose

This study aims to evaluate the actual impact of perioperative levofloxacin eye drops on bacterial colonization density, changes in bacterial spectrum and postoperative infection rates in patients undergoing blepharoplasty.

Methods

This single-center retrospective cohort study reviewed the electronic medical records of 215 patients who underwent blepharoplasty between January 2023 and January 2025.

n = 215 patients

Results

infection risk dropped to nearly 1 in 40 patients with the drops

OR by subgroup · 95% CI

More results

Multivariate regression analysis showed that levofloxacin use was a protective factor for postoperative infection (OR = 0.23, 95% CI: 0.07-0.81), while a history of diabetes was an independent risk factor (OR = 3.47, 95% CI: 1.14-10.55).

More results

There was no significant difference in the time to wound healing between the two groups (7.5 ± 1.2 days vs 7.7 ± 1.4 days, p = 0.258).

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Conclusion

Perioperative levofloxacin eye drops may reduce ocular surface bacterial colonization and the risk of postoperative infection in blepharoplasty patients without delaying wound healing.

Effects of levofloxacin eye drops on ocular surface bacterial colonization and postoperative infection rate in patients undergoing blepharoplast.

Effects of levofloxacin eye drops on ocular surface bacterial colonization and postoperative infection rate in patients undergoing blepharoplast.

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