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New research · Ophthalmology
Orbit (Amsterdam, Netherlands) · 4d
ReviewOrbit (Amsterdam, Netherlands) · 2026

Marin-Amat syndrome: a comprehensive review of pathophysiology, clinical presentation, and management.

Charbel Saad, Christophe Sammour, Terry Nguyen … Rolf Gemperli
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OphthalmologyReview

Bell's palsy is the most common cause of Marin-Amat syndrome

Marin-Amat syndrome: a comprehensive review of pathophysiology, clinical presentation, and management.

Charbel Saad … Rolf Gemperli
Orbit (Amsterdam, Netherlands) · 2026
Background

Marin-Amat syndrome is a rare, acquired facial synkinesis characterized by involuntary eyelid closure upon jaw opening.

Purpose

This scoping review aims to clarify the pathophysiology, clinical presentation, and optimal treatment modalities for Marin-Amat syndrome.

Methods

A comprehensive search was conducted on PubMed, Scopus, Embase, and Web of Science databases following PRISMA-ScR guidelines.

n = 37 patients
Results

in the small case series reviewed, Bell's palsy caused most cases

Bell's palsy
73%
Iatrogenic/surgical in
8.1%
Trauma
8.1%
COVID-19-associated pa
8.1%
More results

Twenty articles met inclusion criteria, comprising 37 patients.

The mean age was 55.8 ± 23.3 years.

Electrophysiologic and clinical descriptions supported active orbicularis oculi co-contraction consistent with post-paralytic synkinesis, with a margin reflex distance-1 reduction of roughly 0.5-2.5 mm on jaw opening.

More results

Botulinum toxin type A directed at the orbicularis oculi produced effective but transient control.

“
Conclusion · 1 of 2

Marin-Amat syndrome is a distinct clinical entity resulting from aberrant regeneration of the facial nerve.

Conclusion · 2 of 2

Botulinum toxin is effective for temporary management, while surgical myectomy combined with ptosis correction represents the definitive treatment for long-term functional and aesthetic restoration.

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