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Cohort studyAntibiotics (Basel, Switzerland) · 2026

Pathogen Spectrum and Antimicrobial Susceptibility Profiles in Culture-Proven Endophthalmitis at a Tertiary Referral Center in China: A Three-Decade Retrospective Study.

Wenfei Zhang, Zhe Yang, Jingjia Zhang … Huan Chen

OphthalmologyCohort study

Staphylococcal ciprofloxacin resistance was much higher in patients over 55

Pathogen Spectrum and Antimicrobial Susceptibility Profiles in Culture-Proven Endophthalmitis at a Tertiary Referral Center in China: A Three-Decade Retrospective Study.

Wenfei Zhang … Huan Chen

Antibiotics (Basel, Switzerland) · 2026

Background

Endophthalmitis is a devastating, vision-threatening intraocular infectious disease.

Purpose

The present study aimed to identify the culture-positive pathogen profiles and antimicrobial susceptibility in endophthalmitis.

Methods

This retrospective study included 90 culture-positive isolates from patients with endophthalmitis treated between January 1990 and October 2020.

n = 90 culture-positive isolates

Results

71.4%

in older patients, staph bacteria much more often resisted this antibiotic

n = 90 culture-positive isolates

More results

Forty-three isolates were Gram-positive cocci, 23 were Gram-negative bacilli, and 24 were fungi.

Postoperative infections were dominated by Gram-positive cocci (72.1%).

Furthermore, 47.8% (11/23) of Gram-negative bacilli and 66.7% (16/24) of fungi were recovered from endogenous endophthalmitis isolates.

More results

All isolates of Gram-positive cocci exhibited full susceptibility to vancomycin and teicoplanin, while linezolid yielded a susceptibility rate of 96.9% (31/32).

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Conclusion · 1 of 3

Postoperative infection was the leading cause of Gram-positive cocci endophthalmitis.

Conclusion · 2 of 3

Antimicrobial susceptibility profiles validated intravitreal vancomycin combined with ceftazidime as a rational regimen for empirical antibacterial coverage.

Conclusion · 3 of 3

Elevated fluoroquinolone resistance among Gram-positive cocci, particularly in elderly patients, underscores the necessity of sustained regional antimicrobial resistance surveillance and periodic reassessment of conventional topical antibiotic prophylatic protocols.

Pathogen Spectrum and Antimicrobial Susceptibility Profiles in Culture-Proven Endophthalmitis at a Tertiary Referral Center in China: A Three-Decade Retrospective Study.

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