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New research · Ophthalmology
Antibiotics (Basel, Switzerland) · 4d
Cohort studyAntibiotics (Basel, Switzerland) · 2026

Pathogen Spectrum and Antimicrobial Susceptibility Profiles in Culture-Proven Endophthalmitis at a Tertiary Referral Center in China: A Three-Decade Retrospective Study.

Wenfei Zhang, Zhe Yang, Jingjia Zhang … Huan Chen
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OphthalmologyCohort study

Staphylococcal ciprofloxacin resistance was much higher in patients over 55

Pathogen Spectrum and Antimicrobial Susceptibility Profiles in Culture-Proven Endophthalmitis at a Tertiary Referral Center in China: A Three-Decade Retrospective Study.

Wenfei Zhang … Huan Chen
Antibiotics (Basel, Switzerland) · 2026
Background

Endophthalmitis is a devastating, vision-threatening intraocular infectious disease.

Purpose

The present study aimed to identify the culture-positive pathogen profiles and antimicrobial susceptibility in endophthalmitis.

Methods

This retrospective study included 90 culture-positive isolates from patients with endophthalmitis treated between January 1990 and October 2020.

n = 90 culture-positive isolates
Results
71.4%
in older patients, staph bacteria much more often resisted this antibiotic
n = 90 culture-positive isolates
More results

Forty-three isolates were Gram-positive cocci, 23 were Gram-negative bacilli, and 24 were fungi.

Postoperative infections were dominated by Gram-positive cocci (72.1%).

Furthermore, 47.8% (11/23) of Gram-negative bacilli and 66.7% (16/24) of fungi were recovered from endogenous endophthalmitis isolates.

More results

All isolates of Gram-positive cocci exhibited full susceptibility to vancomycin and teicoplanin, while linezolid yielded a susceptibility rate of 96.9% (31/32).

“
Conclusion · 1 of 3

Postoperative infection was the leading cause of Gram-positive cocci endophthalmitis.

Conclusion · 2 of 3

Antimicrobial susceptibility profiles validated intravitreal vancomycin combined with ceftazidime as a rational regimen for empirical antibacterial coverage.

Conclusion · 3 of 3

Elevated fluoroquinolone resistance among Gram-positive cocci, particularly in elderly patients, underscores the necessity of sustained regional antimicrobial resistance surveillance and periodic reassessment of conventional topical antibiotic prophylatic protocols.

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