Non-infectious Uveitis is Associated With Increased Psychiatric Comorbidities: An All of Us research program…

Case-controlAmerican journal of ophthalmology· Jul 2026

Non-infectious Uveitis is Associated With Increased Psychiatric Comorbidities: An All of Us research program Analysis.

Priya Marella, Vijay Subramanian, Miriam Habiel

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UveitisCase-controlClinical practiceQ1IF 4.2

Non-infectious uveitis is linked to much higher odds of mood disorders.

Non-infectious Uveitis is Associated With Increased Psychiatric Comorbidities: An All of Us research program Analysis.

Priya Marella … Miriam Habiel

American journal of ophthalmology · Jul 2026 · Q1 in Ophthalmology

Purpose

This study aims to evaluate the psychiatric comorbidities of non-infectious uveitis (non-infectious uveitis) and screening tool usage through a matched case-control approach.

Methods

Retrospective cross-sectional study.

n = 3,266

Results

eye inflammation patients had much higher odds of also having a mood disorder

OR 3.31 (95% CI 3.08 to 3.56)

null 1

3.08

3.56

CI excludes the null - significant

More results

The association between non-infectious uveitis and depression, anxiety, substance and opioid abuse was stronger in Black participants than White participants.

The frequency of PHQ-2 and PHQ-9 questionnaire usage was low among non-infectious uveitis patients with a total of 4.8% and 1.4% respectively.

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Conclusion · 1 of 2

Non-infectious uveitis is strongly associated with psychiatric comorbidities, particularly in Black patients.

Conclusion · 2 of 2

Ophthalmologic examination and the use of screening tools for psychiatric comorbidities can provide early observation of symptoms and is recommended in non-infectious uveitis patients.

Non-infectious Uveitis is Associated With Increased Psychiatric Comorbidities: An All of Us research program Analysis.

Non-infectious Uveitis is Associated With Increased Psychiatric Comorbidities: An All of Us research program Analysis.

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