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New research · Ophthalmology
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 4d
Animal / preclinicalAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026

An Aggregation-Induced Polymerization Poly(Disulfide)-Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS-STING Pathway.

Yuelan Wu, Wenbo Geng, Qinjin Dai … Peizeng Yang
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OphthalmologyAnimal / preclinical

New nanoplatform crossed the blood-retinal barrier far better than the free drug alone.

An Aggregation-Induced Polymerization Poly(Disulfide)-Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS-STING Pathway.

Yuelan Wu … Peizeng Yang
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Background

Autoimmune uveitis is a sight-threatening inflammatory disease in which the cGAS-STING signaling pathway exacerbates inflammation by recognizing excessive cell-free DNA (cfDNA).

Results
5.09-fold
the new nanoplatform crossed into the eye's retina far more easily than the plain drug
More results

This platform is designed to synergistically inhibit the cGAS-STING pathway and achieve efficient intraocular drug delivery.

LA/dexamethasone phosphate functioned as an efficient scavenger of cfDNA through electrostatic interaction, thereby inhibiting cGAS-STING overactivation.

More results

In an experimental autoimmune uveitis mouse model, LA/dexamethasone phosphate treatment significantly reduced cfDNA levels and inhibited cGAS-STING signaling.

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Conclusion

In summary, this study establishes a highly barrier-permeable nanoplatform that synergistically integrates drug delivery with cGAS-STING pathway inhibition, offering a promising therapeutic strategy for autoimmune uveitis.

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